Table 3.
Hazard ratios [95% CI] for the risk of developing secondary IMIDs
| Initial IMID | Secondary IMIDa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | AS | CE | HS | LU | PsA | PsO | RA | UV | IBD | Any 1 | Any 2 | |
| AS | 4,065,648 | – | 11.2 | 3.3 | 23.7 | 50.8 | 8.6 | 63.2 | 54.9 | 16.0 | 31.4 | 35.7 |
| [–, –] | [8.0, 15.5] | [1.5, 7.0] | [19.8, 28.3] | [43.7, 59.0] | [7.4, 10.1] | [58.6, 68.2] | [48.5, 62.3] | [13.5, 19.0] | [29.7, 33.1] | [31.2, 40.7] | ||
| CE | 11,539,665 | 4.0 | – | 4.0 | 8.7 | 2.8 | 5.4 | 6.0 | 5.3 | 17.6 | 7.8 | 4.5 |
| [2.7, 6.2] | [–, –] | [2.9, 5.6] | [7.5, 10.0] | [2.0, 3.8] | [4.8, 6.0] | [5.4, 6.6] | [4.3, 6.4] | [16.0, 19.3] | [7.4, 8.3] | [3.8, 5.4] | ||
| HS | 8,461,932 | 4.4 | 3.2 | – | 4.1 | 2.7 | 6.7 | 4.6 | 5.3 | 5.6 | 5.4 | 3.0 |
| [2.7, 7.1] | [2.3, 4.6] | [–, –] | [3.2, 5.2] | [1.8, 4.1] | [5.9, 7.6] | [4.0, 5.3] | [4.2, 6.8] | [4.7, 6.7] | [5.0, 5.8] | [2.3, 3.8] | ||
| LU | 19,842,102 | 15.5 | 11.5 | 7.5 | – | 7.8 | 5.1 | 41.8 | 9.7 | 7.0 | 18.9 | 10.0 |
| [13.1, 18.3] | [10.1, 13.1] | [6.1, 9.1] | [–, –] | [6.7, 9.1] | [4.6, 5.5] | [40.5, 43.2] | [8.7, 10.8] | [6.3, 7.8] | [18.4, 19.4] | [9.1, 11.0] | ||
| PsA | 5,389,121 | 71.4 | 5.3 | 10.5 | 14.1 | – | 163.2 | 91.5 | 10.0 | 7.3 | 62.2 | 75.2 |
| [60.2, 84.6] | [3.6, 7.7] | [7.3, 15.1] | [11.8, 16.8] | [–, –] | [155.0, 171.9] | [86.4, 96.9] | [8.1, 12.2] | [5.9, 8.9] | [59.9, 64.6] | [69.3, 81.7] | ||
| PsO | 74,343,272 | 5.8 | 5.5 | 8.5 | 4.7 | 197.3 | – | 7.9 | 4.5 | 4.1 | 13.0 | 14.3 |
| [5.1, 6.7] | [5.0, 6.1] | [7.7, 9.4] | [4.3, 5.1] | [191.8, 203.0] | [–, –] | [7.6, 8.2] | [4.1, 4.8] | [3.9, 4.4] | [12.7, 13.2] | [13.7, 15.0] | ||
| RA | 68,911,818 | 78.5 | 10.3 | 8.1 | 55.3 | 46.9 | 7.2 | – | 8.2 | 7.6 | 16.8 | 14.0 |
| [74.1, 83.1] | [9.5, 11.1] | [7.2, 9.1] | [53.7, 57.0] | [45.0, 48.9] | [6.9, 7.5] | [–, –] | [7.7, 8.8] | [7.2, 8.0] | [16.5, 17.1] | [13.3, 14.7] | ||
| UV | 22,200,869 | 89.3 | 4.8 | 6.9 | 8.6 | 5.5 | 4.2 | 11.1 | – | 8.7 | 9.6 | 9.6 |
| [82.6, 96.7] | [3.9, 5.8] | [5.6, 8.6] | [7.7, 9.5] | [4.6, 6.4] | [3.8, 4.6] | [10.6, 11.8] | [–, –] | [8.0, 9.6] | [9.3, 9.9] | [8.7, 10.5] | ||
| IBD | 42,440,304 | 13.4 | 15.1 | 8.0 | 5.6 | 2.3 | 5.0 | 7.4 | 10.2 | – | 7.5 | 4.6 |
| [11.8, 15.3] | [13.9, 16.4] | [7.0, 9.1] | [5.1, 6.1] | [1.9, 2.8] | [4.7, 5.3] | [7.1, 7.8] | [9.5, 11.0] | [–, –] | [7.3, 7.8] | [4.2, 5.1] | ||
Hazard of developing a secondary IMID condition for case patients relative to control patients conditional on being in the initial IMID condition sample. Ratios above 1 indicate a higher risk for case patients than control patients
aSecondary IMIDs were identified by presence of at least one claim with an ICD-9 diagnosis code for that secondary IMID