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Processes in postmitotic neurons that are altered in the gene encoding phosphatase and tensin homolog (PTEN) loss. (A) Regulation of growth cone collapse. (B) Regulation of spine density, morphology, and excitability. (C) Regulation of synaptic plasticity. (D) Regulation of axonal myelination. sEPSC, Spontaneous excitatory postsynaptic current; PI3K, phosphatidylinositol 3-phosphate kinase; NMDA, N-methyl-d-aspartate; LTP, long-term potentiation; LTD, long-term depression.
