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Cell culture–adapted JFH-2 virus genome. Full cell culture–adapted JFH-2 virus genomes were analyzed. Eight and ten adaptive mutations were found in the mtT3 and mtT4 genomes, respectively. These JFH2/AS(mtT3) and JFH2/AS(mtT4) clones were capable of autonomous replication and produced infectious virus in cell culture. Other cell culture–adapted hepatitis C virus (HCV) strains also possess several adaptive mutations (as summarized in Ramirez and Bukh 2018).
