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PTEN residues that affect subcellular localization. PTEN (PDB: 1D5R) interfaces with the membrane at the top of the structure. Residues colored in red are necessary for membrane binding and localization. Mutation of the blue residues result in increased nuclear localization. CLS, cytoplasmic localization sequence (Denning et al. 2007). (Structure from Lee et al. 1999.)
