Table 1.

PTEN molecular functions and impacted cellular phenotypes

Molecular function	Molecular target(s)	Cellular phenotype	References
Lipid phosphatase	PIP3	↓ Cell growth and survival ↓ Migration ↓ Cell spreading	Myers et al. 1998; Davidson et al. 2010; Tibarewal et al. 2012
Protein phosphatase	PTK6, FAK	↓ Migration ↓ Cell spreading	Tamura et al. 1998; Wozniak et al. 2017
	CREB	↓ Transcription of growth-related genes	Gu et al. 2011
	FANC proteins?	↑ DNA repair	Bassi et al. 2013; Vuono et al. 2016
Nonenzymatic (scaffolding)	APC/C	↑ Delay of G1-S transition	Song et al. 2011
	PREX2	↓ Migration	Mense et al. 2015
	RPA1, OTUB1	↑ RPA1-mediated resolution of stalled replication forks	Wang et al. 2015