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LV total collagen (upper panel) and collagen volume fraction (CVF, lower panel) in WKY receiving vehicle (Vh, light gray bars) or Ac-SDKP (dark gray), as well as SHR treated with Vh (hatched light gray) or Ac-SDKP (hatched dark gray). After 4 months of treatment, Ac-SDKP significantly reduced LV collagen deposition in the hypertensive rats. Baseline 10-month-old WKY and SHR are represented by white and hatched white bars, respectively.
