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Ex vivo passive LV PV curves in KCl-arrested hearts of vehicle (○) and Ac-SDKP SHR (●) as well as age-matched WKY receiving vehicle (▼) or Ac-SDKP (■). Despite the LV total collagen reduction achieved in SHR receiving Ac-SDKP, curves were similar to nontreated SHR, suggesting that at our experimental pressures, total collagen is not a major determinant of passive stiffness. 0 μL=initial volume reached at 0 mm Hg pressure.
