Reduction of Cardiac Fibrosis Decreases Systolic Performance Without Affecting Diastolic Function in Hypertensive Rats

. Author manuscript; available in PMC: 2019 Nov 1.

Published in final edited form as: Hypertension. 2004 Mar 15;43(5):1067–1073. doi: 10.1161/01.HYP.0000125013.22494.c5

HR, BW, LVW/BW, LVEDV, MCSA, and τ of WKY and SHR at Baseline and After 4 Months of Treatment With Ac-SDKP or Vehicle

	Baseline		After 4 Months
Parameters	WKY-10 (n=6)	SHR-10 (n=7)	WKY-14 (Vh) (n=8)	WKY-14 (Ac) (n=9)	SHR-14 (Vh) (n = 7)	SHR-14 (Ac) (n=8)
HR	257 ±12	326 ±24^*	315±30	340±13	392 ±47^*	408± 23^*
BW (g)	674±41	384 ±14^*	719±31	691±17	395 ±45^*	427 ±14^*
LVW/BW (mg/g)	1.7±0.1	2.5±0.1^*	1.54±0.1	1.56±0.2	2.9±0.1^*	2.8±0.1^*
LVEDV (μL)	690 ±56	610±31	719±45	760 ±25	650 ±33^*	684 ±19^*
MCSA (μm²)	380 ±22	480 ±12^*	485±13	479±17	551 ±27^*	525 ±49^*
τ (msec)	12±0.2	15±0.3^*	12±0.4	11.6±0.7	16.3±1.3^*	17.2±0.7^*

HR indicates heart rate; BW, body weight; LVW, left ventricular weight; LVEDV, left ventricle end-diastolic volume; MCSA, myocyte cross-sectional area; t, a determinant of LV end-diastolic relaxation; WKY, Wistar-Kyoto Rats; SHR, spontaneously hypertensive rats; Vh, vehicle; Ac, Ac-SDKP.

P<0.05 vs age-matched WKY. At this age, WKY are larger than SHR. Treatment did not significantly affect hypertrophy, LVDV, or relaxation in either strain.