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. 2019 Nov 1;33(21-22):1575–1590. doi: 10.1101/gad.322776.118

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© 2019 Kim et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — SMEDWI-3 binds a diverse class of genic piRNAs. (A) Mapping of immunoprecipitated piRNAs to the planarian genome uncovers a distinct class of genic piRNAs bound to SMEDWI-3. piRNA counts weighted by the number of places they map to were used for the genomic annotation of piRNAs. (B) SMEDWI-3-bound piRNAs mapped to gene-coding regions show a strong sense bias. (C) Coverage profile of RNA-seq and immunoprecipitated piRNAs for traf-6 (SMESG000000371.1). The gene loci are highlighted in blue. A neighboring transposable element is highlighted in gray. (D) Ping-pong analysis of transcripts producing sense piRNAs. Nucleotide composition analysis of total piRNAs mapped to processed transcripts confirms the involvement of the ping-pong cycle. (E) Heatmap showing the enrichment of predicted InterPro protein domains in transcripts with mapped genic piRNAs.