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. 2019 Nov 1;33(21-22):1575–1590. doi: 10.1101/gad.322776.118

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© 2019 Kim et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — SMEDWI-3 group 1 ping-pong targets form nuclear foci in the planarian epidermis. (A) Boxplots showing the log₂ fold differential expression changes of the three distinct SMEDWI-3 target groups upon smedwi-3 knockdown in neoblasts (X1) and differentiated cells (Xins). Statistical significance of differential expression of the gene sets was assessed using generally applicable gene-set enrichment (GAGE) analysis with a two-sample t-test (ns, not significant). (B) GO term enrichment analysis of ping-pong degraded group 1 SMEDWI-3 targets. (C) Expression and localization pattern of three exemplary ping-pong targets of SMEDWI-3 [dapk1 (SMESG000043474.1), traf6 (SMESG000000294.1), ank1 (SMESG000076223.1)] in the planarian epidermis analyzed with whole-mount in situ hybridization (WISH). Nuclei stained with Hoechst are in blue, mRNAs are in yellow. (D) Coimmunostaining of SMEDWI-1, -2, and -3 in the epidermis on a cross-section through the planarian pharynx. SMEDWI-1 is in green, SMEDWI-2 and -3 are in red. Nuclei stained with DAPI are in blue.