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. 2019 Nov 1;33(21-22):1539–1554. doi: 10.1101/gad.328682.119

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© 2019 Morafraile et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 6. — Topological defects explain the genetic interactions and DNA damage in the sld3-A dbf4-A strain. (A–E) Fivefold dilution growth assays of the indicated strains. (F) Quantification of nuclear fragmentation after nuclear separation in the indicated strains. Image of yeast containing Htb2-mcherry (red) and myo1-GFP (green) is shown. Fragmentation was considered only for Htb2 signal that was >0.1 µm from the rest of the nucleus (white arrow). Error bars are SD from n = 3. (G,H) Quantification of Rad52-GFP foci in the indicated strains released from G1 phase (0 min) into 200 mM HU in YP galactose medium. Error bars are SD, n = 3.