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. 2019 Nov 1;33(21-22):1525–1538. doi: 10.1101/gad.330167.119

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© 2019 Tatomer et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — The Integrator complex cleaves nascent MtnA RNAs to catalyze premature transcription termination. (A) Northern blotting was used to analyze RNAs generated from the endogenous MtnA locus in DL1 cells treated with the indicated dsRNAs and CuSO₄. Full-length MtnA mRNA (black arrow) and Integrator-dependent small RNAs (orange) are indicated. (B) Parental DL1 cells (lanes 1–4) or DL1 cells stably expressing WT (lanes 5–8) or catalytically inactive (lanes 9–12) IntS11 transgenes were treated with the indicated dsRNAs and CuSO₄. Northern blotting was then performed as in A.