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. 2019 Sep 27;50(11):3004–3012. doi: 10.1161/STROKEAHA.119.026545

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© 2019 American Heart Association, Inc.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Derivation of a common variant genetic factor XI (FXI) score. A, The genetic FXI score was derived based on 2 common, intronic variants (rs4253417 and rs1593) with previously described effects on FXI levels¹⁰ and aPTT.¹¹ B, Possible combinations of genotypes for the 2 variants showed a range from 0% to 6.8% genetically determined relative activated partial thromboplastin time (aPTT) increase. C, Distribution of score values in the UK Biobank.