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. 2019 Sep 27;50(11):3004–3012. doi: 10.1161/STROKEAHA.119.026545

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© 2019 American Heart Association, Inc.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Analysis of fit of effect estimates of individual genotype groups to the log-linear model. Effects for (A) myocardial infarction, (B) ischemic stroke, (C) venous thromboembolism, and (D) major bleeding. Effect estimates for the categorical version of the factor XI (FXI) score where each level corresponds to a specific combination of genotypes of rs4253417 and rs1593 (black) show good fit to the log-linear model (green). Effects of FXI loss-of-function variants in 50k whole-exome sequences (red) were broadly consistent with the linear model, although CIs were wide because of the limited sample size of 477 FXI LOF variant carriers.