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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Am Chem Soc. 2017 Jul 25;139(31):10641–10644. doi: 10.1021/jacs.7b05893

Table 4.

Hydroheteroarylation of Various Alkynes with Indolea

graphic file with name nihms-1026097-t0008.jpg
a

1a (0.1 mmol), 2 (0.12 mmol), [Rh(COD)Cl]2 (2.5 mol%), (R)-DTBM-BINAP (5.0 mol%), (PhO)2P(O)OH (50 mol%), CPME (0.2 mL), 60 °C. Isolated yields. rr’s (3:4) determined by 1H NMR analysis of the unpurified reaction mixture. Enantioselectivities determined by chiral SFC.