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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Nat Chem. 2018 Jul 30;10(9):968–973. doi: 10.1038/s41557-018-0089-5

Figure 2. Synthesizing cyclic dehydropeptides using dehydroamino acids.

Figure 2

a, Synthesis and elongation of linear dehydropeptide is enabled using oxazolones and (±)-β-phenylserine. b, Macrocyclization of linear dehydropeptides proceeds at high concentration. Boc, t-butyloxycarbonyl; TFA, trifluoroacetic acid; DMAP, 4-dimethylaminopyridine; rt, room temperature.