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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Nat Chem. 2018 Jul 30;10(9):968–973. doi: 10.1038/s41557-018-0089-5

Figure 4. Mechanistic experiments support a unidirectional hydrogenation.

Figure 4

a, 19F-NMR time trace supports sequential reduction. b, Subjecting the synthesized intermediates to standard hydrogenation conditions yields cyclic peptide 6a’ with high diastereoselectivity.