Table 2.

HnB products assessed in the included studies

HnB product and manufacturer	Release date, place	Description	Studies
Pax by Ploom (now PAX Labs)	2012, USA	Loose-leaf tobacco and cannabis vaporiser. Loose tobacco is placed into a chamber and heated by an electrically powered element.40 A predecessor of Ploom Tech by JTI.	40
IQOS/THS 2.2 by PMI	2014, Japan, Italy and Switzerland	IQOS includes a holder, a charger and tobacco sticks (Heets). A tobacco stick (about 320 mg) is inserted into the holder and the tobacco is heated with an electronically controlled heating blade which is inserted into tobacco plug. Operating heating temperature<350°C. A single use lasts 6 min or up to 14 puffs.61 Under ISO conditions, 12 puffs of the THS 2.2 yield 0.5 mg nicotine and 4.9 mg glycerol.44	5 21–27 29 31–35 39 41–45 48 49
iFuse by BAT	2015, Romania	iFuse includes an electronic vapour device with a rechargeable Li-ion battery and an integrated circuit power controller, onto which a cartomiser (Neopod) is attached. The disposable neopod comprises an atomiser, a liquid tank with 1.15 mL of non-flavoured nicotine liquid and a chamber containing a 130 mg tobacco plug. When the user presses a button, nicotine-containing vapour is produced, which is then drawn through the tobacco plug to absorb flavours. Before reaching the tobacco plug, the aerosol reaches an average maximum of <35°C.30	30
Glo/THP 1.0 by BAT	2016, Japan	Glo includes an electronic device with a rechargeable Li-ion battery and a heating chamber and tobacco sticks. A tobacco stick (about 260 mg) is heated in the heating chamber from the periphery. Operating heating temperature <250°C. Reaches operating temperature after 30–40 s and a single use lasts for another 3 min.28	5 28 29 36 41 51
Ploom Tech/PNTV by JTI	2016, Japan	PNTV includes a power supply unit, a cartridge with a heater and liquid and a capsule with tobacco blend. Generates a nicotine-free vapour by heating the unflavoured liquid; the vapour then passes through the tobacco capsule to absorb flavours and nicotine. Under HCI conditions, 50 puffs yield 1.10 mg nicotine.52	5 41 42 52
Carbon-heated tobacco product (CHTP) by PMI	Not released	A specifically designed electric lighter lights the carbon heating source which then heats a tobacco plug. Under ISO conditions, 12 puffs of the CHTP yield 0.4 mg nicotine and 2 mg glycerol, 3 mg tar and 1 mg CO.47 A predecessor of TEEPS by PMI.	47
IQOS/THS 2.1 by PMI	Not released	THS 2.1 includes a holder, a charger and tobacco sticks. A tobacco stick is inserted into the holder and the tobacco is heated with an electronically controlled heating blade. Operating heating temperature<400°C. A single use lasts 6 min or up to 14 puffs. Under ISO conditions, 12 puffs of the THS 2.1 yield 0.3 mg nicotine and 5 mg glycerol.46 A predecessor of commercially available IQOS/THS 2.2.	46 50

BAT, British American Tobacco; HnB, heat-not-burn tobacco product; ISO, International Organisation for Standardisation; PMI, Philip Morris International; PNTV, Prototype novel tobacco vapour product; JTI, Japan Tobacco International; LLTV, loose-leave tobacco vaporiser; PMI, Philip Morris International; THP, tobacco heating product; THS , tobacco heating system.