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. Author manuscript; available in PMC: 2019 Nov 15.
Published in final edited form as: Int J Cancer. 2019 Feb 20;145(10):2619–2628. doi: 10.1002/ijc.32194

Table 1.

Meta-analysis of thirteen validated SNPs in the fatty acid synthesis pathway using two published melanoma GWAS datasets

SNP Allele1 Gene Position MDACC (n=858) NHS/HPFS (n=409) Meta-analysis (n=1267)
EAF HR (95% CI)2 P2 FPRP3 EAF HR (95% CI)4 P4 FPRP3 Phet I2 HR (95% CI)5 P5
rs37343986 T>C ELOVL2 6p24.2 0.41 0.72 (0.54–0.96) 0.027 0.195 0.42 0.53 (0.33–0.83) 0.005 0.076 0.265 19.44 0.66 (0.51–0.84) 8.34×10−4
rs37987137 G>C ELOVL2 6p24.2 0.43 0.68 (0.51–0.91) 0.019 0.076 0.42 0.52 (0.33–0.82) 0.005 0.067 0.326 0 0.63 (0.50–0.80) 1.74×10−4
rs110376836 A>C HSD17B12 11p11.2 0.06 2.10 (1.22–3.61) 0.007 0.132 0.06 2.52 (1.42–4.46) 0.002 0.060 0.650 0 2.29 (1.55–3.39) 3.61×10−5
rs110376846 A>G HSD17B12 11p11.2 0.06 2.10 (1.22–3.61) 0.007 0.132 0.06 2.52 (1.42–4.46) 0.002 0.060 0.650 0 2.29 (1.55–3.39) 3.61×10−5
rs618838087 A>G HSD17B12 11p11.2 0.06 2.25 (1.31–3.86) 0.003 0.084 0.06 2.23 (1.21–4.10) 0.010 0.198 0.983 0 2.24 (1.49–3.36) 9.42×10−5
rs618838097 A>G HSD17B12 11p11.2 0.06 2.25 (1.31–3.86) 0.003 0.084 0.06 2.40 (1.33–4.33) 0.004 0.108 0.875 0 2.32 (1.55–3.45) 3.68×10−5
rs618838117 T>C HSD17B12 11p11.2 0.06 2.25 (1.31–3.86) 0.003 0.084 0.06 2.40 (1.33–4.33) 0.004 0.108 0.875 0 2.32 (1.55–3.45) 3.68×10−5
rs618838447 T>C HSD17B12 11p11.2 0.06 2.25 (1.31–3.86) 0.003 0.084 0.06 2.34 (1.30–4.23) 0.005 0.125 0.924 0 2.29 (1.54–3.42) 4.77×10−5
rs618838457 G>T HSD17B12 11p11.2 0.06 2.25 (1.31–3.86) 0.003 0.084 0.06 2.34 (1.30–4.23) 0.005 0.125 0.924 0 2.29 (1.54–3.42) 4.77×10−5
rs175145537 T>A HSD17B12 11p11.2 0.06 2.25 (1.31–3.86) 0.003 0.084 0.06 2.34 (1.30–4.23) 0.005 0.125 0.924 0 2.29 (1.54–3.42) 4.77×10−5
rs175991147 C>T HSD17B12 11p11.2 0.06 2.25 (1.31–3.86) 0.003 0.084 0.06 2.34 (1.30–4.23) 0.005 0.125 0.924 0 2.29 (1.54–3.42) 4.77×10−5
rs175986877 A>C HSD17B12 11p11.2 0.06 2.25 (1.31–3.86) 0.003 0.084 0.06 2.23 (1.21–4.10) 0.010 0.198 0.983 0 2.24 (1.49–3.36) 9.42×10−5
rs777394527 T>A HSD17B12 11p11.2 0.06 2.22 (1.29–3.82) 0.004 0.091 0.06 2.40 (1.33–4.33) 0.004 0.108 0.849 0 2.30 (1.54–3.43) 4.34×10−5

Abbreviations: SNP, single-nucleotide polymorphism; GWAS, genome-wide association study; MDACC, The University of Texas MD Anderson Cancer Center; NHS/HPFS, the Nurses’ Health Study and Health Professionals Follow-up Study; EAF, effect allele frequency; HR, hazards ratio; CI, confidence interval; FPRP, false positive report probability; Phet, P value for heterogeneity by Cochrane’s Q test; ELOVL2, elongation of very long-chain fatty acids 2; HSD17B12, hydroxysteroid dehydrogenase type 12;

1

Reference allele/effect allele;

2

Adjusted for age, sex, Breslow thickness, distant/regional metastasis, ulceration and mitotic rate in the additive model;

3

FPRP was used for multiple test correction because 85.1% of the analyzed SNPs in MDACC dataset were imputed with a high level of linkage disequilibrium;

4

Adjusted for age and sex in an additive genetic model;

5

Meta-analysis in the fix-effect model;

6

Genotyped SNPs in the MDACC dataset;

7

Imputed SNPs in the MDACC dataset.