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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Acta Biomater. 2019 May 23;95:131–151. doi: 10.1016/j.actbio.2019.05.051

Figure 2. Material properties that influence vascularization.

Figure 2.

The thickness of the avascular fibrotic layer (shown in light red) can be reduced by constructing an implant that allows cell migration into the membrane (a). Larger pores can facilitate more blood vessel investment than pores that are only sufficiently large enough to allow blood vessels to form (b). Increases in nanotopographical roughness can increase vascularization compared to smooth substrates (c).