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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Acta Biomater. 2019 May 23;95:131–151. doi: 10.1016/j.actbio.2019.05.051

Figure 4. Preparing a site by prevascularization to improve engraftment.

Figure 4.

Preimplantation of a material stimulates vascular enrichment (a). The islets can then be introduced into the preimplanted device (b) or the device can be removed to create a space left by the device that the islets can be introduced into (c). All of these approaches result in a space for the islets that has a greater vascular supply at the time of transplantation than an unprepared site.