Table 4.

Occurrence of neutropenia and associated complications pre- and post-intervention

Neutropenia Characteristics	n (%)		p-value*
	Pre-intervention (n=141)	Post-intervention (n=109)
Patients with any neutropenia	80 (57%)	61 (56%)	0.90
Patients with any neutropenia receiving chemotherapy	6 (8%)	2 (3%)	0.47
Patients with >1 episode	42 (30%)	11 (10%)	<0.001
Patients with >1 episode receiving chemotherapy†	5 (12%)	0 (0%)	0.57
Days post-transplant to first neutropenia episode, Median (Q1, Q3)**	83.0 (60.0, 137.0)	99.0 (52.0, 141.0)	0.23
Ever received GCSF for neutropenia	32 (40%)	28 (46%)	0.48
Ever Neutropenia with fever	25 (31%)	15 (25%)	0.39
Ever Neutropenia requiring hospitalization	38 (48%)	18 (30%)	0.03
Ever Documented blood stream infection	2 (3%)	1 (2%)	0.99
Neutropenia by transplant type			0.10
Kidney	47 (59%)	27 (44%)
Liver	13 (16%)	13 (21%)
Heart	6 (7.5%)	12 (20%)
Lung	7 (9%)	7 (12%)
Multivisceral	7 (9%)	2 (3%)

^†All patients who received chemotherapy had received a liver transplant for hepatoblastoma or other hepatic tumors

^*p-value from fisher’s exact/chi-square test testing for difference in categorical variables pre- and post-intervention.

^**p-value from Mann-Whitney U test comparing distribution of days post-transplant between pre- and post-intervention periods.