Skip to main content
. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Immunol. 2019 Jun 15;202(12):3412–3422. doi: 10.4049/jimmunol.1800587

Figure 8. Maraviroc protects striatal dopamine in hemiparkinsonian monkeys.

Figure 8.

Naïve female rhesus monkeys received a right intracarotid injection of MPTP. After 7 d of injection, monkeys displaying classical parkinsonian postures received maraviroc (1 mg/kg body wt/d) orally mixed with banana. MPTP group of monkeys also received normal banana as control. After 30 d of treatment, dopamine levels were measured in dorsomedial caudate (A), ventromedial caudate (B), dorsal putamen (C), ventral putamen (D), and nucleus accumbens (E). HPLC quantification of dopamine was performed by a single investigator blinded to the experimental conditions. Data are means ± SEM of four monkeys per group. ap < 0.001 vs MPTP-intact; bp < 0.001 vs MPTP-lesion.