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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Pain. 2019 May 2;20(11):1293–1306. doi: 10.1016/j.jpain.2019.04.008

Figure 8. GABAergic signaling in the rostral ventromedial medulla (RVM) underlies RLED-induced thermal hyperalgesia and mechanical allodynia.

Figure 8.

Rats were exposed to RLED for 3 hrs daily for 5 days at 50 Lux. Following RLED exposure, one cohort of rats received injections of bicuculine 20 μM at 0.5 μL to the RVM, while another cohort received injections of sterile water at 0.5 μL to the RVM. (A) Paw withdrawal latencies (measured via Hargreaves test) were significantly increased in bicuculine-injected rats compared to sterile water-injected counterparts (*p<0.05, two-way ANOVA with Tukey’s post hoc analysis, n=4–8) (B) Paw withdrawal thresholds (measured via stimulation with von Frey filaments) and (C) withdrawal thresholds (measured via shoulder stimulation with von Frey filaments) were significantly increased in bicuculine-injected rats compared to sterile water-injected counterparts (*p<0.05, two-way ANOVA with Tukey’s post hoc analysis, n=4–8).