Table 1.
Baseline Characteristics of Sample
| Characteristic | Zolpidem CR | Placebo | Overall | |||
|---|---|---|---|---|---|---|
| Randomized Participants | 51 | 52 | 103 | |||
| M | SD | M | SD | M | SD | |
| Age | 39.7 | 14.5 | 41.2 | 12.0 | 40.5 | 13.2 |
| BMI | 28.3 | 6.4 | 28.2 | 5.6 | 28.2 | 6.0 |
| N | % | N | % | N | % | |
| Female | 32 | 63 | 32 | 62 | 64 | 62 |
| Clinic | ||||||
| 1 | 23 | 45 | 27 | 52 | 50 | 49 |
| 2 | 15 | 29 | 15 | 29 | 30 | 29 |
| 3 | 13 | 25 | 10 | 19 | 23 | 22 |
| Race/Ethnicity | ||||||
| Caucasian/White | 30 | 59 | 33 | 63 | 63 | 61 |
| African American | 12 | 24 | 16 | 31 | 28 | 27 |
| Hispanic | 4 | 8 | 1 | 2 | 5 | 5 |
| Other | 5 | 10 | 2 | 4 | 7 | 7 |
| Antidepressant Trials in Current Episode | ||||||
| 0 | 29 | 57 | 30 | 58 | 59 | 57 |
| 1 | 14 | 27 | 12 | 23 | 26 | 25 |
| 2+ | 8 | 16 | 10 | 19 | 18 | 17 |
| Lifetime Suicide Attempt(s) | 15 | 29 | 16 | 31 | 31 | 30 |
| PTSD | 13 | 25 | 16 | 31 | 29 | 28 |
| Obsessive Compulsive Disorder | 2 | 4 | 3 | 6 | 5 | 5 |
| Generalized Anxiety | 20 | 39 | 21 | 41 | 41 | 40 |
| Panic Disorder with agoraphobia | 9 | 20 | 8 | 17 | 17 | 18 |
| Panic Disorder without agoraphobia | 10 | 20 | 7 | 14 | 17 | 17 |
| M | SD | M | SD | M | SD | |
| Scale for Suicide Ideation; Suicide Ideation Score | 12.2 | 5.3 | 11.8 | 5.3 | 12.0 | 5.3 |
| Scale for Suicide Ideation: Suicide Attempts | N | % | N | % | N | % |
| Never | 36 | 71 | 36 | 69 | 72 | 70 |
| Once | 8 | 16 | 8 | 15 | 16 | 16 |
| Two or more Times | 7 | 14 | 8 | 15 | 15 | 15 |
| Scale for Suicide Ideation: Death Wish | ||||||
| No suicide attempt | 36 | 71 | 36 | 69 | 72 | 70 |
| Low | 3 | 6 | 3 | 6 | 6 | 6 |
| Moderate | 6 | 12 | 4 | 8 | 10 | 10 |
| High | 6 | 12 | 9 | 17 | 15 | 15 |
| M | SD | M | SD | M | SD | |
| C-SSRS Ideation Intensity Past Week | 1.71 | 1.03 | 1.58 | 1.02 | 1.64 | 1.02 |
| N | % | N | % | N | % | |
| C-SSRS: A lot of difficulty or inability to control thoughts | 6 | 12 | 12 | 23 | 18 | 18 |
| C-SSRS: Deterrents probably or definitely stopped suicide attempt | 43 | 86 | 35 | 67 | 78 | 76 |
| CGI-S | ||||||
| Mildly | 3 | 6 | 0 | 0 | 3 | 3 |
| Moderately | 33 | 65 | 32 | 62 | 65 | 63 |
| Markedly | 13 | 25 | 18 | 35 | 31 | 30 |
| Severe | 2 | 4 | 2 | 4 | 4 | 4 |
| M | SD | M | SD | M | SD | |
| HAMD Score | 28.7 | 4.7 | 29.6 | 7.0 | 29.1 | 5.9 |
| Insomnia Severity Index | 20.7 | 4.0 | 21.0 | 4.3 | 20.9 | 4.1 |
| Beck Hopelessness Score | 13.4 | 4.8 | 12.7 | 4.6 | 13.1 | 4.7 |
| Disturbing Dreams and Nightmare Severity Index | 10.5 | 8.8 | 10.2 | 7.7 | 10.3 | 8.2 |
| Dysfunctional Beliefs and Attitudes about Sleep | 6.7 | 1.6 | 6.7 | 1.5 | 6.7 | 1.6 |
| Basis 32: Daily Living and Role Functioning | 2.4 | 0.6 | 2.2 | 0.7 | 2.3 | 0.6 |
| Basis 32: Relationship to Self and Others | 2.5 | 0.6 | 2.2 | 0.7 | 2.3 | 0.7 |
| Mini Mental State Exam Total Score | 29.6 | 0.8 | 29.3 | 1.0 | 29.4 | 0.9 |
| Epworth Sleepiness Scale Score | 7.9 | 5.0 | 8.5 | 4.7 | 8.2 | 4.9 |