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. Author manuscript; available in PMC: 2020 Feb 28.
Published in final edited form as: Mucosal Immunol. 2019 Aug 28;12(6):1382–1390. doi: 10.1038/s41385-019-0196-7

Figure 1. TOLLIP-deficient mice demonstrate enhanced clearance of L. pneumophila (Lp) after aerosol infection.

Figure 1.

Mice were infected with approximately 106 CFU WT Lp Philadelphia-1 strain and at 24, 72, and 144 hours post infection, lungs were harvested. A) Bacterial counts were measured by CFU on BCYE agar plates. B) Total polymorphonuclear cell counts from bronchoalveolar fluid. C) Total mononuclear cells from bronchoalveolar fluid samples. D) Hematoxylin and eosin staining of representative sections of D) WT and E) Tollip−/− mouse lung 72hr after Lp aerosol infection. * p< 0.05, Student’s t-test, two sided. Error bars represent +/− SEM. N = 5 mice in each group at each time point. Data are representative of three independent experiments.