Table 1.

Distribution of TOLLIP rs5743854 G allele in Netherlands cohort.

	Control	Cases	P value	Odds Ratio (95% CI)
N	309	88
Male, f* (n)	0.51 (159)	0.52 (44)	0.128
Age (median, IQR)	49.6 (35.2 – 56.1)	64.7 (54.2 – 71.5)	< 0.001
Smoker, f*(n)	0.31	0.49	0.022
COPD, f (n)	0.10 (24)	0.07 (6)
Diabetes Mellitus, f (n)	0.04 (3)	0.09 (8)
Cancer, f(n)	0.02 (2)	0.04 (4)
Hx. Transplant, f(n)	0.02 (2)	0 (0)
Autoimmune Dz, f(n)	0 (0)	0.02 (2)
Alcohol Use, f(n)	0.73 (61)	0.35 (32)
Rs5743854 genotype			0.008	0.35 (0.16 – 0.76)†
C/C f(n)	0.32 (99)	0.33 (29)
G/C	0.41 (127)	0.52 (46)
G/G	0.27 (83)	0.14 (12)

^*f=frequency

^†recessive genetic model adjusted for gender, age, and comorbidities.