Figure 2.
In vivo anti‐tumor effect of chimeric anti‐coxsackievirus and adenovirus receptor mAbs on a subcutaneous transplanted xenograft model of DU‐145 human prostate cancer cells. Effect of treatment with ch6G10A on the in vivo growth of DU‐145 cells. DU‐145 cells (1 × 107 cells) were implanted s.c. into BALB/c nude mice. Treatment started when average tumor volume had reached 100 mm3 (as day 0). A total of 500 μg of ch6G10A, control human IgG or saline was injected i.v. at days 0 and 7 (indicated by arrows). Human natural killer (NK) cells KHYG‐1/Fcγ receptor IIIA (4 × 105 cells) were injected around the tumors at days 0 and 7 (indicated by arrows). A, Tumor volume. B, Tumor weight at 11 days. Results are expressed as means ± SD (IgG control; n = 7, ch6G10A; n = 5). Statistical analysis was carried out by Student's t test (*P < .05, **P < .01, n.s., not significant)