Figure 5.
In vivo anti‐tumor effect of mouse coxsackievirus and adenovirus receptor (CAR) mAb on an orthotopic transplanted xenograft model of the highly metastatic subline of DMS273 human small cell lung cancer (SCLC) cells. A‐B, Effect of treatment with mu6G10A on the in vivo growth of C5B cells, the highly metastatic subline of DMS273, in an orthotopic transplanted xenograft model. C5B cells (2.5 × 105 cells) were orthotopically transplanted into the lungs of BALB/c nude mice (day 0). Total of 250 μg of mu6G10A or control mouse IgG was injected i.v. once a week from day 1 for 5 weeks. Mice were killed and analyzed on days 30‐39. A, Orthotopic tumor volume at the time of death. B, Distant metastatic formation. Dotted lines show the means of the number of metastasis‐positive organs of each group. Percentages show distant metastasis incidence. Results are expressed as means ± SD (n = 9). Statistical analysis was carried out by Student's t test (*P < .05, ***P < .005 vs control)