Figure 5.

Disks large‐associated protein 5 (DLGAP5) expression in prostate cancer tissues. A, mRNA expression level of DLGAP5 in castration‐resistant prostate cancer (CRPC) tissues. DLGAP5 expression in CRPC tissues was analyzed by using data in the two Oncomine datasets (Varambally et al33 and Grasso et al32). B, Representative images of immunohistochemistry (IHC) of DLGAP5 in prostate cancer tissues. Representative images of negative and positive immunoreactive (IR) cases of prostate cancer specimens and CRPC tissues are shown. (Arrows, positive cells; scale bar, 50 μm). C, Positive expression of DLGAP5 is associated with poor prognosis of prostate cancer patients. Cancer‐specific survival of prostate cancer patients is shown (n = 95). Survival curve was obtained by Kaplan‐Meier method and P‐value was determined by log‐rank (Mantel‐Cox) test. D, Rate of cases in which positive IR was detected by DLGAP5 IHC in benign, prostate cancer (PCa), and CRPC tissues. Chi‐squared test was done to calculate P‐value