Figure 3.

A stemlike gene signature is associated with poor patient survival and glutaminolysis‐related gene expression in head and neck squamous cell carcinoma (HNSCC). A, Kaplan‐Meier plots of overall survival for patients with HNSCC tumors characterized by CD44v9^high or CD44v9^low (left) or CD44v9^high/involucrin^low or CD44v9^low/involucrin^high (right) gene expression signatures. Data are from the TCGA cohort. P values were determined with the log‐rank test. B, Box‐whisker plot of the expression of KRT10 (differentiation marker) and glutaminolysis‐related (SLC1A5, SLC6A15, SLC38A5, GLS, GLUD1 and GLUD2) genes on the CD44v9^high/involucrin^low and CD44v9^low/involucrin^high gene signatures for head and neck squamous cell carcinoma (HNSCC) tumors in the TCGA cohort. **P < 0.01 (Student's t test); NS, not significant