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. 2019 Sep 20;110(11):3486–3496. doi: 10.1111/cas.14187

Figure 6.

Figure 6

Erythropoietin‐producing hepatocellular carcinoma receptor A6 (EPHA6) gain‐of‐function impedes glioblastoma multiforme tumor growth in a mouse orthotopic model. A, Survival curve of mice inoculated with TGS‐01‐luc (luciferase) cells infected with ad‐LacZ or ad‐EPHA6‐KD and pretreated or not pretreated with 200 ng/mL BMP‐2 for 2 d. n = 4 for all groups except the EPHA6‐KD group treated with BMP‐2 (n = 3). LacZ + BMP‐2 vs EPHA6‐KD + BMP‐2 (*P < .05); LacZ vs EPHA6‐KD (**P < .01). B, Tumor formation shown by luciferase signals in the groups of mice as in experiment (A) at 3 wk‐time point. cps, count per second. C, Survival curve of mice inoculated with TGS‐01‐luc cells infected with ad‐LacZ, ad‐EPHA6‐WT, or ad‐EPHA6‐KD pretreated with 200 ng/mL BMP‐2 for 2 d. n = 5 for all groups. LacZ + BMP‐2 vs EPHA6‐WT + BMP‐2 (**P < .01); LacZ + BMP‐2 vs EPHA6‐KD + BMP‐2 (**P < .01). (D) Tumor formation shown by luciferase signals in the groups of mice as in experiment (C) at the 3‐wk time point. One mouse from LacZ + BMP‐2 group was omitted in the survival analysis (C) due to premature death during anesthesia.