Figure 5.

Activation of the epithelial growth factor receptor (EGFR) signaling pathway with E‐cadherin‐Fc chimera protein (E‐cad‐Fc) treatment. Upper panel: Quantitative analysis in two independent western blotting experiments. E‐cad‐Fc treatment of ornithine decarboxylase‐degron–transduced cells markedly enhanced phosphorylation of EGFR, AKT, ERK1/2, mTOR, and PI3K, although total expression of each molecule was not affected. *P < .05, **P < .01, ***P < .001. Lower panel: Representative blots are shown