Figure 1.

AZD9291 fails to inhibit phosphorylation of the epidermal growth factor receptor (EGFR) downstream AKT and ERK1/2, in EGFR TKI‐resistant HCC827 cells. A, Parental and AZD9291‐resistant HCC827 cells were lysed, and phosphorylation of the EGFR downstream targets AKT and ERK1/2 was detected by western blotting. B, HCC827, HA1, and HA2 cells were treated with AZD9291 for 3 h, and whole‐cell lysates were analyzed by western blotting. Data are representative of three separate experiments