Figure 4.

Efficacy of SHR‐A1403 on AZD9291‐resistant HA1 xenografts overexpressing c‐mesenchymal‐epithelial transition factor (c‐Met) in vivo. A, Nude mice bearing HCC827 or HA1 xenografts were treated with vehicle, 10 mg/kg SHR‐A1403 or 3 mg/kg AZD9291, and tumor volume and body weights were measured on the indicated days. B and C, Nude mice bearing HA1 xenografts were i.v. injected with 3 mg/kg AZD9291 or 10 mg/kg SHR‐A1403 once, then tumor tissues were lysed in RIPA buffer, and analyzed by western blotting. Results shown represent means ± SEM (vehicle group, n = 8; SHR‐A1403 group, n = 6). ****P < .0001 vs vehicle