Table 34.
Clinical signs–other organ systems
| N (%)a | |
|---|---|
| Metabolic | |
| Elevated anion gap (> 20) | 286 (4.1) |
| Metabolic acidosis (pH < 7.2) | 276 (3.9) |
| Hypoglycemia (glucose < 50 mg/dL) | 122 (1.7) |
| Elevated osmole gap (> 20) | 28 (0.4) |
| Total | 535 (7.6)b |
| Renal/musculoskeletal | |
| Acute kidney injury (creatinine > 2.0 mg/dL) | 285 (4.0) |
| Rhabdomyolysis (CPK > 1000 IU/L) | 263 (3.7) |
| Total | 478 (6.8)b |
| Hematological | |
| Coagulopathy (PT > 15 s) | 139 (2.0) |
| Leukocytosis (WBC > 20 K/μL) | 82 (1.2) |
| Thrombocytopenia (platelets < 100 K/μL) | 80 (1.1) |
| Hemolysis (Hgb < 10 g/dL) | 47 (0.7) |
| Methemoglobinemia (MetHgb ≥ 2%) | 23 (0.3) |
| Pancytopenia | 7 (0.1) |
| Total | 310 (4.4)b |
| Gastrointestinal/hepatic | |
| Hepatotoxicity (AST ≥ 1000 IU/L) | 220 (3.1) |
| Gastrointestinal bleeding | 40 (0.6) |
| Pancreatitis | 29 (0.4) |
| Corrosive injury | 24 (0.3) |
| Intestinal ischemia | 4 (0.1) |
| Total | 294 (4.2)b |
| Dermatological | |
| Rash | 100 (1.4) |
| Blister/Bullae | 75 (1.1) |
| Angioedema | 31 (0.4) |
| Necrosis | 20 (0.3) |
| Total | 193 (2.7)b |
AST aspartate aminotransferase, PT prothrombin time, WBC white blood cells, Hgb hemoglobin, CPK creatine phosphokinase
aPercentage equals the number of cases reporting specific clinical signs compared to the total number of Registry cases in 2018 (N = 7043)
bTotal reflects cases reporting at least one sign in the category. Cases may be associated with more than one symptom