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. 2019 Mar 21;35(4):649–654. doi: 10.1007/s12288-019-01114-9

Table 4.

Comparison with previously published literature

Published studies ORR Median PFS Median OS
Pagano et al. [14] 55% (median DOR = 16.4 months) 12.6 months (range, 0.5–75.8), with a survival at 5 years was 9.3%
Musto et al. [15] 60.8% (post 4 cycles) 52.1% (15 months) 65.2% (15 months)
Musto et al. [16] 92% 8 months 12 months
D Arena et al. [17] 79% 55% (2 years)
Colovic et al. [18] 7/30 patients achieved remission 4.5 months
García-Sanz et al. [19] 37% (ORR = 29% + PR = 8%) 8 months
Mahindra et al. [20]
 Autologous SCT 76% (at transplant) 34% at 3 years 64% at 3 years
 Allogeneic SCT 64% (at transplant) 20% at 3 years 39% at 3 years

Drake et al. [21]

Autologous SCT

41.2%

(at day 100 post SCT)

25.7 (19.5–31.9 months)

Pagano et al. [14]

SCT

HR for relapse 0.13,

(95% CI 0.04–0.41)

38.1 months

(range 4.8–75.8 months)

Our study

Median follow up-22 months

70%

(post induction chemotherapy)

11 months

(95% C.I. 6.3–15.6)

21 months

(95% C.I. 1–49.8)