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. 2019 Nov 1;9:15812. doi: 10.1038/s41598-019-52143-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Linsitinib significantly abrogates Kitra-SRS tumour growth in xenograft mouse models. (a–d) Mice bearing Kitra-SRS xenografts were treated with either 50 mg/kg linsitinib or vehicle (five mice/group). Tumour volume and body weight during treatment (a,d) and tumour weight and the appearance of resected tumours at the end point (b,c) are shown. (e) Immunohistochemical staining showing expression of Ki-67 in each treatment group. (f) Quantification of Ki-67-positive cells in Kitra-SRS tumours from each treatment group (five fields counted/group). (g) Tumour tissues from Kitra-SRS xenografts at the end point were harvested, and lysates were prepared for western blot analyses using the indicated antibodies. Data in a bar graph represent the mean value ± SD. **p < 0.01; significantly different from the vehicle group.