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. 2019 Nov 1;9:15825. doi: 10.1038/s41598-019-52142-4

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© The Author(s) 2019, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo Biodistribution of GalNAc@PEG@siRNA-PLGA. The mice were injected intravenously at a single dose of free siRNA, PEG@siRNA-PLGA, GalNAc@PEG@scr-siRNA-PLGA and GalNAc@PEG@siRNA-PLGA. siRNA concentration was determined at 1 h, 2 h, 6 h, 12 h and 24 h time points in Liver (A), Kidney (B), Spleen (C) and Blood (D). Data are the means ± SD of three sets of different experiments. Statistical analysis was compared by one-way ANOVA followed by Dunnett’s post hoc test. *P < 0.05, **P < 0.01 for NC versus Free siRNA; *P < 0.05, **P < 0.01 for NC versus PEG@siRNA-PLGA.