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. 2019 Nov 1;9:15848. doi: 10.1038/s41598-019-52174-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rifampicin induction in dinaciclib pre-treated Huh7s. (A) Non-treated Huh7 cells were incubated with 0 μM, 5 μM, 10 μM and 20 μM rifampicin, an inducer of CYP3A4 through PXR, for 24 hrs. The mRNA levels of CYP3A4 and PXR were quantified via quantitative real-time PCR. (B) Dinaciclib pre-treated Huh7 cells were incubated with the same rifampicin concentrations. A gradual increase in fold-expression levels of CYP3A4 and PXR is observed. The data are presented as mean ± SEM. N = 6, *p ≤ 0.05, **p ≤ 0.01.