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. 2019 Nov 1;9:15848. doi: 10.1038/s41598-019-52174-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CYP inducibility in dinaciclib pre-treated Huh7s. (A) Non-treated Huh7 cells were incubated with increasing rifampicin concentrations for 24 hrs. The mRNA levels of CYP1A2, CYP2C9, CYP2C19, and CYP2E1 were quantified via quantitative real-time PCR. Out of these four enzymes, the first three are regulated by PXR whereas CYP2E1 is not. (B) The same experiment was performed in dinaciclib pre-treated Huh7 cells. The data are presented as mean ± SEM. N = 6, **p ≤ 0.01, ***p ≤ 0.001.