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. 2019 Nov 1;3:27. doi: 10.1038/s41698-019-0099-9

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — R-propranolol significantly suppressed tumor growth in vivo. bEnd.3 cells allografted into mice formed tumors within 2 weeks of inoculation, and treatment with R-propranolol significantly reduced the tumor volume within 2 weeks of tumor development (p = 0.014). Five animals were included in each of the control and the treatment groups, depicted by individual dot in the graph. All statistical analyses were performed using GraphPad Prism (GraphPad Software, La Jolla, CA)