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. 2019 Nov 1;3:27. doi: 10.1038/s41698-019-0099-9

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — R-propranolol alters changes in the expression of proteins identified in RNAseq, validating the findings. Immunohistochemistry for ANGPTL4, BHMT, and APOA1 were performed on paraffin-embedded samples of R-propranolol- or ethanol vehicle-treated bEnd.3 murine tumor to validate the differential expression analysis results obtained using RNAseq. Nuclear expression of ANGPTL4 was markedly reduced in R-propranolol-treated animals while BHMT and APOA1 expression was increased in the experimental group, supporting the RNAseq findings. a, b Control- and R-propranolol-treated tumor samples stained with ANGPTL4. c, d Control- and R-propranolol-treated tumor samples stained with BHMT. e, f Control- and R-propranolol-treated tumor samples stained with APOA1. Scale bars indicate 50 μm in all panels