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. 2019 Nov 1;9:15847. doi: 10.1038/s41598-019-52127-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RGD protein bearing extracellular vesicles (EVs) promote platelet adhesion under flow. (a,b) Fluorescence images of representative time-lapse recording demonstrate firm binding of CFSE-labelled platelets on the luminal surface of the isolated mouse MCA pre-treated with EVs isolated from sham and tMCAO animals, and in the presence of physiological pressure and flow (white arrowheads show stationary platelets). (c) Summary data show adhered platelets (white arrow heads) under basal condition, and after the endothelium was removed with air (De-endo), or when sham EVs or EVs from tMCAO were delivered prior to platelets. Data are mean ± SEM, *p < 0.05.