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. 2019 Nov 1;9:15808. doi: 10.1038/s41598-019-52386-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Schematic representation of binding interaction among CCM proteins within CSC complex. Our current data suggests that CCM1 utilizes 2^nd and 3^rd NPXY motifs (pY) in its center portion to bind to CCM2 classic PTB domain (PTB). The remaining 1^st NPXY motif competes with the CCM3 (FAT-H) to bind to the newly defined atypical PTB domain (aPTB) present at the C – terminus of the CCM2, suggesting CCM2 plays a central role in the CSC. CCM1: blue color; CCM2: light green color; CCM3: red color.