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Kinetic analysis of the interactions between NPXY motif of CCM1 and two cores of novel aPTB domain.
| Method | BLI | ITC | |
|---|---|---|---|
| Affinity | KD (M) | KD (M) | |
| Ligand | CCM1-K8 | CCM1-K8 | CCM1-K2 |
| CCM2-EX6 | 4.06 × 10−6 | 1.99 × 10−6 | 6.45 × 10−6 |
| CCM2-Ex6A | 2.97 × 10−5 | NA | 6.02 × 10−5 |
| CCM2-Ex6B | NA | NA | NA |
Affinity data obtained using two different platforms (BLI and ITC) were presented. Binding affinity is presented with the equilibrium dissociation constant (KD). NA: not available due to undetectable binding.
