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. 2019 Nov 1;10:4991. doi: 10.1038/s41467-019-13004-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The probability of GABA released onto CA1 pyramidal cells is altered in Ts2Cje mice. a Evoked IPSCs (eIPSCs) by inhibitory terminals at distal regions of the CA1 pyramidal cell dendrites. Left, layout of the positions of recording and stimulation electrodes. Middle, sample traces normalized to the second response and superimposed, from the three different genotypes. Right, box plot showing that the paired pulse ratio was reduced in Ts2Cje mice—indicating increased probability of GABA release—and its recovery upon Grik1 normalization (n = 14 for euploid, n = 13 for Ts2Cje, n = 14 for TsGrik1^+/−, one-way ANOVA+Holm–Sidak). b Paired pulse ratio of eIPSCs obtained by stimulating inhibitory terminals proximal to the CA1 pyramidal cell soma. Left, position of stimulation and recording electrodes. Middle, sample traces normalized to the second response. Right, box plot showing increased paired pulse ratio—indicating reduced probability of GABA release—in Ts2Cje and its recovery to euploid levels in TsGrik1^+/− littermates (n = 27 for euploid, n = 15 for Ts2Cje, n = 19 for TsGrik1^+/−, one-way ANOVA+Holm–Sidak). For detailed data values and statistics, see Supplementary Table 3. *p < 0.05, ***p < 0.005