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. 2019 Nov 1;9:15853. doi: 10.1038/s41598-019-52388-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of shared and tissue-specific genes differentially expressed in blood and spleen over the course of P. chabaudi infection. (a) Number of tissue-specific (Blood = 116, Spleen = 322) and shared (10) immune-related DEGs. (b) Subclassification of tissue-specific and shared genes by day in log scale. (c) Heatmap of expression values (−2 < Z-score > 2) for the 10 immune-related genes shared between blood and spleen over the course of infection. (d) Reactome “Interleukin signalling” diagram showing the number of tissue-specific genes present in each process irrespective of the day of infection. Given the high level of diversity in the number of immune processes at each time point, Interleukin signalling was selected because it was the only process present at more than one time point (4 and 6 d.p.i) and had the highest significance.