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. 2019 Nov 1;10:4986. doi: 10.1038/s41467-019-12983-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Chemotherapy + Decitabine combination prevents chemoresistance in hAML cells. a Schematic diagram of the experimental system used. T0 indicates the time of treatment initiation and Trelapse is defined as the post-therapy time point when re-grown hAML reached equivalent numbers as T0. NT–no treatment; DAC–decitabine (0.1 μM); Doxo–doxorubicin (1.8 μM); Cyta–cytarabine (6μM). b Total number of viable HEL and OCI-AML3 barcoded cells between T0 and Trelapse, defined as a fold variation of cell number at each measured time point relatively to T0 (n = 3 for NT and DAC, n = 5 for Cyta and Doxo, n = 8 for Doxo + Cyta and Doxo + Cyta + DAC, independent replicates). T box indicates the period of therapy exposure. c Frequency of viable Trelapse HEL and OCI-AML3 barcoded cells (NT: n = 12/9, Doxo: n = 6/8, Doxo + Cyta: 13/10 and Doxo + Cyta + DAC: 13/8, independent replicates in HEL / OCI-AML3 respectively) after re-exposure to Doxo + Cyta for 72 h. Concerning panels b and c displayed graphs show mean ± s.d.; P values were determined by one-way ANOVA test. ns–not significant, *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Source data are provided as a Source Data file