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. 2019 Nov 1;9:15835. doi: 10.1038/s41598-019-50963-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network analyses for the smoking (SM) genes. (A) GGM network for the SM genes (BH $p \leq 0.05$ ). Genes which had no significant connections (partial correlation) were left out of the figure, and the genes connected in only one of the tissues are colored in grey. In blue: edges present in bronchial tissue. In red: edges present in nasal tissue. In magenta: edges present both tissues (Overlapped edges). (B) Scatter plot of the GGM network edges (partial correlation) for the SM genes. Each red dot represents $- l o g_{10} (BH p)$ of an edge in bronchial tissue (horizontal axis) versus nasal tissue (vertical axis). In light black: the critical value at BH $p \leq 0.05 .$ The figure displays the respective gene pairs for the most similar edges. (C) 22 significant GOs for the set of Overlapped genes. The enrichment is contrasted against two sets of genes randomly sampled from the SM (27 genes) and from the whole genome (19718 genes). The panel displays the corresponding mean $- l o g_{10}$ (p-values), and error bars represent + 2 standard errors over the 500 random samples.